Abstract
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Autocrine Communication / immunology
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Autocrine Communication / physiology*
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Biophysical Phenomena
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Biophysics
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Cells, Cultured
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Dendritic Cells / immunology
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Dendritic Cells / physiology
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Interferons / physiology
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Ligands
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Models, Biological*
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Paracrine Communication / immunology
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Paracrine Communication / physiology