Insight into the reactive form of the anticancer agent iproplatin

Erika Volckova; Evelyne Weaver; Rathindra N Bose

doi:10.1016/j.ejmech.2007.06.019

Insight into the reactive form of the anticancer agent iproplatin

Eur J Med Chem. 2008 May;43(5):1081-4. doi: 10.1016/j.ejmech.2007.06.019. Epub 2007 Jul 10.

Authors

Erika Volckova¹, Evelyne Weaver, Rathindra N Bose

Affiliation

¹ Michael Faraday Laboratory, Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States.

PMID: 17707553
DOI: 10.1016/j.ejmech.2007.06.019

Abstract

The reaction of iproplatin with reduced glutathione at different mole ratios yielded cis-di(isopropylamine)chloro-glutathionatoplatinum(II), not the expected cis-dichloro- species, indicating a mode of action of this anticancer agent that is different from that of cis-diamminedichloroplatinum(II).

MeSH terms

Antineoplastic Agents / chemistry*
Chromatography, High Pressure Liquid
Glutathione / chemistry*
Magnetic Resonance Spectroscopy
Organoplatinum Compounds / chemistry*
Spectrometry, Mass, Electrospray Ionization

Substances

Antineoplastic Agents
Organoplatinum Compounds
iproplatin
Glutathione