A novel analgesic pyrazine derivative from the leaves of Croton tiglium L

J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):437-41. doi: 10.1080/10286020500384781.

Abstract

A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice.

MeSH terms

  • Analgesics / chemistry
  • Analgesics / isolation & purification*
  • Analgesics / pharmacology
  • Animals
  • Croton / chemistry*
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Plant Leaves / chemistry*
  • Pyrazines / chemistry
  • Pyrazines / isolation & purification*
  • Pyrazines / pharmacology

Substances

  • 2-(furan-2-yl)-5-(2,3,4-trihydroxybutyl)-1,4-diazine
  • Analgesics
  • Pyrazines