Abstract
A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice.
MeSH terms
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Analgesics / chemistry
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Analgesics / isolation & purification*
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Analgesics / pharmacology
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Animals
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Croton / chemistry*
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Plant Leaves / chemistry*
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Pyrazines / chemistry
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Pyrazines / isolation & purification*
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Pyrazines / pharmacology
Substances
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2-(furan-2-yl)-5-(2,3,4-trihydroxybutyl)-1,4-diazine
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Analgesics
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Pyrazines