The aim of this theoretical review was to articulate the resilience concept with key aspects in the lives of people living with HIV/AIDS. We emphasize the analysis of protective factors traditionally related to resilience (personal characteristics and social and affective support networks). The reviewed studies show important protective factors that contribute to the health and well-being of people with HIV/AIDS, such as cognitive coping and acceptance of their HIV status, family participation in treatment and family support, the role of governmental and nongovernmental institutions, and religious beliefs. The concept of resilience defined as a dynamic process that allows human beings to overcome adversities is essential for understanding HIV infection and treatment of AIDS patients. It helps decrease stigmatization and prejudice towards the disease and patients. It also helps alter the notion that living with AIDS is incompatible with well-being and quality of life and fosters the creation of new HIV/AIDS prevention and treatment perspectives.