Abstract
We describe the synthesis of 1,omega-di-1H-imidazoles 2 and 3, derived from l-threitol and d-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for 1H spectroscopic imaging by magnetic resonance methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Chemistry
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Cell Line, Tumor
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Extracellular Space / chemistry
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Hydrogen-Ion Concentration
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Indicators and Reagents / chemical synthesis
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Indicators and Reagents / chemistry
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Indicators and Reagents / pharmacology
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Magnetic Resonance Spectroscopy / methods*
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Neoplasms / chemistry*
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Rats
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Rats, Wistar
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Stereoisomerism
Substances
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(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole
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(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole
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Imidazoles
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Indicators and Reagents