Evaluation of a new pressure ulcer preventive dressing containing ceramide 2 with low frictional outer layer

J Adv Nurs. 2007 Sep;59(5):520-9. doi: 10.1111/j.1365-2648.2007.04334.x.

Abstract

Aim: This paper is a report of an evaluation of the effectiveness of a newly developed dressing for preventing persistent erythema and pressure ulcer development and improving the water-holding capacity without increasing the skin pH in bedridden older patients.

Background: Shear forces and skin dryness play important roles in persistent erythema and pressure ulcer development. To eliminate these risks, we developed a dressing to reduce shear forces and improve the water-holding capacity. However, the effects of this dressing in clinical settings remain unknown.

Method: An experimental bilateral comparison study was conducted at a hospital in Japan in 2004 with 37 bedridden older patients at risk of pressure ulcer development. The dressing was randomly applied to the right or left greater trochanter for 3 weeks. No dressing was applied to the opposite side as a control. The skin was monitored weekly during the 3-week application for persistent erythema and pressure ulcer development. Skin hydration and pH were also assessed during the intervention and for 1 week after dressing removal.

Findings: The incidence of persistent erythema was significantly lower in the intervention area than the control area [P = 0.007, RR 0.18 (95% CI: 0.05-0.73) and NNT 4.11 (2.50-11.63) ]. No pressure ulcers occurred in either the intervention or control area. Skin hydration increased significantly during dressing application and remained high after removal (P < 0.001) relative to the control area. Skin pH decreased significantly during the application (P < 0.001) but returned to control levels after removal (P = 0.38).

Conclusion: This safe and effective dressing can be used for patients with highly prominent bones and dry skin to prevent pressure ulcers.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Bandages*
  • Biomechanical Phenomena
  • Ceramides / pharmacology
  • Ceramides / therapeutic use*
  • Chronic Disease
  • Emollients / pharmacology
  • Emollients / therapeutic use*
  • Erythema / physiopathology
  • Erythema / prevention & control*
  • Female
  • Friction
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Male
  • Pressure Ulcer / physiopathology
  • Pressure Ulcer / prevention & control*
  • Skin / physiopathology
  • Skin Aging
  • Treatment Outcome
  • Water Loss, Insensible / drug effects

Substances

  • Ceramides
  • Emollients