[Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines]

O A Volokh; I A Shepelev; V V Firsova; E M Khramkova; N G Avdeeva; Iu I Samokhvalova; S A Eremin; I A Diatlov; V E Zhemchugov

[Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines]

Zh Mikrobiol Epidemiol Immunobiol. 2007 May-Jun:(3):16-21.

[Article in Russian]

Authors

O A Volokh, I A Shepelev, V V Firsova, E M Khramkova, N G Avdeeva, Iu I Samokhvalova, S A Eremin, I A Diatlov, V E Zhemchugov

PMID: 17672125

Abstract

Data on influence of Francisella tularensis C-complex preparations on formation of immunity against tularemia are presented. Study of cellular immunity characteristics as well as dynamics of antibody response was carried out on white mice and guinea pigs models. Absence of toxicity, pyrogenicity, and negative effects on immunocompetent cells in combination with protective activity points to possibility of use the C-complex as a component of a subunit vaccine.

MeSH terms

Animals
Antibodies, Bacterial / blood
Apoptosis
Bacterial Proteins / immunology
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / immunology*
Bacterial Vaccines / toxicity
Cells, Cultured
Drug Evaluation, Preclinical
Francisella tularensis / immunology*
Guinea Pigs
Lymphocyte Activation
Membrane Proteins / immunology
Mice
Spleen / physiology
Thymus Gland / physiology
Tularemia / blood
Tularemia / immunology*
Tularemia / prevention & control*
Vaccination*
Vaccines, Synthetic / administration & dosage
Vaccines, Synthetic / immunology
Vaccines, Synthetic / toxicity

Substances

Antibodies, Bacterial
Bacterial Proteins
Bacterial Vaccines
Membrane Proteins
Vaccines, Synthetic