Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring

Chembiochem. 2007 Sep 3;8(13):1491-4. doi: 10.1002/cbic.200700196.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / chemistry
  • Actinobacteria / metabolism
  • Adenylyl Cyclases / genetics*
  • Adenylyl Cyclases / metabolism
  • Benzoquinones / chemistry*
  • Benzoquinones / metabolism*
  • Catalysis
  • Chromatography, Liquid
  • Enzyme Inhibitors / metabolism*
  • HSP90 Heat-Shock Proteins / metabolism
  • Hydro-Lyases / chemistry
  • Hydro-Lyases / genetics*
  • Hydro-Lyases / metabolism
  • Lactams, Macrocyclic / metabolism*
  • Mass Spectrometry
  • Molecular Conformation
  • Mutation / genetics*
  • Streptomyces / chemistry
  • Streptomyces / metabolism

Substances

  • Benzoquinones
  • Enzyme Inhibitors
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • quinone
  • 3-amino-5-hydroxybenzoic acid synthase
  • Hydro-Lyases
  • Adenylyl Cyclases
  • adenylyl cyclase 2
  • geldanamycin