[Cytology and immunophenotype feautures of 80 acute myeloid leukemia]

Tunis Med. 2007 May;85(5):393-7.
[Article in French]

Abstract

Acute myeloid leukemia (AML)'s diagnosis is clinical and biological. We report here 80 AML with cytology and immunophenotype features to establish correlations. 21 AML1, 23 AML2, 12 AML3, 2 AML4, 18 AML5 and 3 AML6 were diagnosed by cytology. Only one case of AML0 was diagnosed by immunophenotype. Myelogysplasia is present in 29.8% cases. CD19 and CD56 expression was significantly associated to AML +t(8;21). Additionally, concomitant negativity of CD34 and HLA-DR was discrimininatif to AML3 diagnosis. Prognostic value to expression some CD needs time backwards.

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD19 / analysis
  • Antigens, CD34 / analysis
  • B-Lymphocytes / pathology
  • CD56 Antigen / analysis
  • Child
  • Child, Preschool
  • Female
  • HLA-DR Antigens / analysis
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Leukemia, Myeloid, Acute / classification
  • Leukemia, Myeloid, Acute / immunology
  • Leukemia, Myeloid, Acute / pathology*
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / immunology
  • Myelodysplastic Syndromes / pathology
  • Myeloid Cells / pathology
  • Peroxidase / analysis
  • Prognosis
  • T-Lymphocytes / pathology

Substances

  • Antigens, CD19
  • Antigens, CD34
  • CD56 Antigen
  • HLA-DR Antigens
  • Peroxidase