Cu-catalyzed tandem C-N bond formation for the synthesis of pyrroles and heteroarylpyrroles

Org Lett. 2007 Aug 16;9(17):3379-82. doi: 10.1021/ol7014225. Epub 2007 Jul 27.

Abstract

A highly efficient Cu-catalyzed tandem C-N bond-forming reaction of 1,4-dihalo-1,3-dienes has been developed. The transformation allows the synthesis of pyrroles and heteroarylpyrroles with a wide variety of functional groups and substitution patterns from readily available precursors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis
  • Catalysis
  • Copper / chemistry*
  • Heterocyclic Compounds / chemical synthesis
  • Hydrocarbons, Halogenated / chemical synthesis
  • Pyrroles / chemical synthesis*

Substances

  • Alkenes
  • Heterocyclic Compounds
  • Hydrocarbons, Halogenated
  • Pyrroles
  • Copper