Breakthrough invasive pulmonary aspergillosis despite empirical voriconazole therapy for febrile neutropenia: case report and review of the literature

Scand J Infect Dis. 2007;39(8):731-3. doi: 10.1080/00365540701199857.

Abstract

We report the development of invasive pulmonary aspergillosis in a patient treated for acute myeloid leukaemia during empirical voriconazole therapy for febrile neutropenia. The patient failed to respond to the institution of salvage combination therapy with amphotericin B and voriconazole, but survived after adjunctive surgical resection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy
  • Aspergillosis / surgery*
  • Drug Resistance, Fungal / drug effects*
  • Fever / microbiology
  • Humans
  • Leukemia, Myeloid / complications
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / surgery*
  • Male
  • Middle Aged
  • Neutropenia / microbiology
  • Pyrimidines / therapeutic use*
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole