High level group analysis of FMRI data based on Dirichlet process mixture models

Inf Process Med Imaging. 2007:20:482-94. doi: 10.1007/978-3-540-73273-0_40.

Abstract

Inferring the position of functionally active regions from a multi-subject fMRI dataset involves the comparison of the individual data and the inference of a common activity model. While voxel-based analyzes, e.g. Random Effect statistics, are widely used, they do not model each individual activation pattern. Here, we develop a new procedure that extracts structures individually and compares them at the group level. For inference about spatial locations of interest, a Dirichlet Process Mixture Model is used. Finally, inter-subject correspondences are computed with Bayesian Network models. We show the power of the technique on both simulated and real datasets and compare it with standard inference techniques.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms*
  • Brain / physiology*
  • Brain Mapping / methods*
  • Computer Simulation
  • Evoked Potentials / physiology*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Models, Neurological*