Abstract
HIV-1 Rev is an indispensable regulatory factor of the virion protein expression. The interaction between Rev and RRE RNA accelerates the nuclear export of viral mRNA. The unspliced and singly spliced mRNA will be degraded in the absence of Rev, resulting in the interception of HIV-1 replication at the same time. The pivotal role that Rev plays in HIV-1 replication as a trans-acting factor makes it a new target in the research of AIDS drugs. In this review, the function of Rev, Rev-RRE interaction, as well as their related inhibitors are reported.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus
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Amino Acid Sequence
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Cell Nucleus / metabolism
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Exportin 1 Protein
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / pharmacology
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Framycetin / chemistry
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Framycetin / pharmacology
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HIV-1 / genetics*
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HIV-1 / metabolism
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HIV-1 / physiology
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Karyopherins / metabolism
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RNA, Messenger / genetics
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RNA, Viral / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism
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Transcription, Genetic
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Virus Replication*
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rev Gene Products, Human Immunodeficiency Virus / antagonists & inhibitors*
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rev Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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Anti-HIV Agents
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Fatty Acids, Unsaturated
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Karyopherins
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RNA, Messenger
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RNA, Viral
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Receptors, Cytoplasmic and Nuclear
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rev Gene Products, Human Immunodeficiency Virus
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rev protein, Human Immunodeficiency Virus-1
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Framycetin
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leptomycin B