Pea seedling histaminase as a novel therapeutic approach to anaphylactic and inflammatory disorders. A plant histaminase in allergic asthma and ischemic shock

ScientificWorldJournal. 2007 Jun 12:7:888-902. doi: 10.1100/tsw.2007.139.

Abstract

Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amine Oxidase (Copper-Containing) / therapeutic use*
  • Anaphylaxis / drug therapy*
  • Asthma / drug therapy*
  • Brain Ischemia / complications
  • Brain Ischemia / drug therapy*
  • Humans
  • Hypersensitivity / drug therapy*
  • Inflammation / drug therapy*
  • Phytotherapy / methods
  • Phytotherapy / trends
  • Pisum sativum / enzymology*
  • Plant Extracts / therapeutic use
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'
  • Seeds / enzymology
  • Shock / etiology
  • Shock / prevention & control

Substances

  • Plant Extracts
  • Amine Oxidase (Copper-Containing)