Abstract
This tutorial review provides a historical sampling of synthetic efforts undertaken in our laboratory, which have led to the total syntheses of a range of small molecule natural products of potential interest in oncology. It has become evident that natural products, and structures clearly derivable from natural products, have a remarkable record in the treatment of cancer at the clinical level. It is likely that, with the growing power of chemical synthesis, small molecule natural products will play a continuing role in providing lead anticancer compounds.
MeSH terms
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Amaryllidaceae Alkaloids / chemical synthesis
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Amaryllidaceae Alkaloids / chemistry
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Antibiotics, Antineoplastic / chemical synthesis
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Antibiotics, Antineoplastic / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Isoquinolines / chemical synthesis
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Isoquinolines / chemistry
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Mitomycins / chemical synthesis
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Mitomycins / chemistry
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Tubulin Modulators / chemical synthesis
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Tubulin Modulators / chemistry
Substances
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Amaryllidaceae Alkaloids
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Antibiotics, Antineoplastic
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Antineoplastic Agents
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Enzyme Inhibitors
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Isoquinolines
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Macrolides
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Mitomycins
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Tubulin Modulators
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pancratistatin