Laboratory incubation trials were conducted to investigate the effects of several factors on the persistence as well as the dissipation of three synthetic pyrethroid pesticides in red soils obtained from the Yangtze River Delta region in China. The pyrethroids selected for investigation were cypermethrin, fenvalerate, and deltamethrin, which continue to be used extensively to control pests on farmland in the region despite the concern that they are highly toxic to certain vertebrate and mammalian species. Data from this exploratory study showed that the dissipation half-lives (T (1/2)) tended to correlate with soil pH and soil organic matter contents, but not with soil cation-exchange capacity. The T (1/2) values were seen to be shorter in soil samples fertilized with glucose than without. The rates of pyrethroid dissipation also tended to increase with increasing initial soil concentration, but were largely unaffected by whether the pesticides were present in the soil separately or as a mixture. Another noteworthy observation is that microbial activity appeared to dominate the degradation process. Findings of this type could offer valuable clues for future research directions in reducing pesticide persistence in soil, which in turn could lead to the ultimate reduction of environmental pollution caused by pyrethroid application to farmland in the region.