Abstract
We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Electrophoresis, Gel, Two-Dimensional / methods
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Hyperthyroidism / chemically induced
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Hyperthyroidism / metabolism
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Hypothyroidism / chemically induced
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Hypothyroidism / metabolism
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Male
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Muscle Proteins / metabolism*
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Muscle, Skeletal / metabolism*
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Proteome / metabolism*
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RNA, Messenger / metabolism
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Rats
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Rats, Wistar
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
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Thyroid Gland / drug effects
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Thyroid Gland / metabolism*
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Thyroid Hormones / pharmacology
Substances
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Muscle Proteins
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Proteome
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RNA, Messenger
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Thyroid Hormones