Abstract
Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
MeSH terms
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Membrane / metabolism
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Cell Membrane / ultrastructure
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Centrioles / genetics
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Centrioles / metabolism
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Centrioles / ultrastructure
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Centrosome / metabolism*
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Centrosome / ultrastructure
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Cilia / genetics
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Cilia / metabolism*
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Cilia / ultrastructure
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Humans
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Mitosis / genetics*
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Phosphotransferases / genetics
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Phosphotransferases / metabolism*
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Spindle Apparatus / genetics
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Spindle Apparatus / metabolism*
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Spindle Apparatus / ultrastructure
Substances
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Cell Cycle Proteins
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Phosphotransferases