Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils

Joana A Macedo; Judith Hesse; Jonathan D Turner; Wim Ammerlaan; Andrea Gierens; Dirk H Hellhammer; Claude P Muller

doi:10.1016/j.jneuroim.2007.06.002

Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils

J Neuroimmunol. 2007 Aug;188(1-2):159-66. doi: 10.1016/j.jneuroim.2007.06.002. Epub 2007 Jun 28.

Authors

Joana A Macedo¹, Judith Hesse, Jonathan D Turner, Wim Ammerlaan, Andrea Gierens, Dirk H Hellhammer, Claude P Muller

Affiliation

¹ Institute of Immunology, Laboratoire National de Santé, Luxembourg.

PMID: 17602758
DOI: 10.1016/j.jneuroim.2007.06.002

Abstract

Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
Cytokines / metabolism*
Dexamethasone
Female
Fibromyalgia / immunology
Fibromyalgia / metabolism*
Fibromyalgia / pathology*
Humans
L-Selectin / metabolism*
Male
Middle Aged
Monocytes / metabolism*
Neutrophils / metabolism*
Statistics, Nonparametric

Substances

Cytokines
L-Selectin
Dexamethasone