Current hypothesis of neuronal degeneration in Parkinson's disease (PD) have been proposed, including formation of free radicals and oxidative stress, mitochondrial dysfunction, excitotoxicity, trophic factor deficiency, inflammatory processes, genetic factors, environmental impact factors, toxic action of nitric oxide, apoptosis, and so on. This review mainly discussed oxidative stress, environmental impact factors, and inflammatory processes in PD.
目前, 帕金森病的发病机理存在各种假说, 包括氧化应激与清除自由基能力下降、 线粒体功能异常、 兴奋性氨基酸的毒性作用、 神经营养因子的缺乏、 神经炎症机制、 基因与环境影响因素、 一氧化氮毒性作用 和凋亡等。 本文就帕金森病的氧化应激、 环境影响因素、 神经炎症机制作一综述。