Objective: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular (CV) mortality. This study compared different criteria including Sokolow-Lyon and Cornell, in terms of voltage and voltage-QRS-duration products, as well as point-scoring systems such as the Romhilt-Estes, Perugia and Glasgow-Royal-Infirmary modified Romhilt-Estes score.
Methods: Patients undergoing echocardiography were recruited from the cardiology department in Glasgow Royal Infirmary. Echocardiographically derived left ventricular mass was indexed to body surface area and using sex dependent thresholds, LVH was determined. Electrocardiograms (ECG) were processed using The University of Glasgow Analysis Program, permitting different LVH criteria to be calculated and evaluated. Inclusion criteria for this study were that the patients had a technically adequate echocardiogram and ECG.
Results: The main analysis used 51 male and 76 female patients. At published thresholds, the Lewis index gave the greatest sensitivity of the voltage criteria (12%). However, adjusted to 95% specificity, the Cornell index produced the greatest sensitivity at 19%. The best voltage-duration product was the Cornell product that gave 15% sensitivity and 19% when adjusted to 95% specificity. The point scoring systems proved to be the most accurate with the Perugia score being 22% sensitive and the Glasgow Royal Infirmary modified Romhilt-Estes score 24 % sensitive, both at 95% specificity.
Conclusion: This study finds that ECG criteria for LVH that use only voltage are relatively poor predictors of LVH. This study also finds that the best criteria for assessing LVH are the point scoring criteria, in particular the Glasgow Royal Infirmary Modified Romhilt-Estes score.