A new subtype of MLL-SEPT2 fusion transcript in therapy-related acute myeloid leukemia with t(2;11)(q37;q23): a case report and literature review

Cancer Genet Cytogenet. 2007 Jul 1;176(1):72-5. doi: 10.1016/j.cancergencyto.2007.04.001.

Abstract

The t(2;11)(q37;q23) is a rare recurrent cytogenetic abnormality associated with de novo and therapy-related acute myeloid leukemia, resulting in a MLL-SEPT2 fusion gene. We report on a case of therapy-related acute myeloid leukemia M2 showing a t(2;11)(q37;q23) and resulting in a new subtype of a MLL-SEPT2 chimeric transcript. The literature on this translocation is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 2*
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Oncogene Proteins, Fusion*
  • Phosphoric Monoester Hydrolases / genetics*
  • Translocation, Genetic*

Substances

  • KMT2A protein, human
  • Oncogene Proteins, Fusion
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase
  • Phosphoric Monoester Hydrolases