Abstract
The t(2;11)(q37;q23) is a rare recurrent cytogenetic abnormality associated with de novo and therapy-related acute myeloid leukemia, resulting in a MLL-SEPT2 fusion gene. We report on a case of therapy-related acute myeloid leukemia M2 showing a t(2;11)(q37;q23) and resulting in a new subtype of a MLL-SEPT2 chimeric transcript. The literature on this translocation is reviewed.
MeSH terms
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Aged
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 2*
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Histone-Lysine N-Methyltransferase
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Male
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Myeloid-Lymphoid Leukemia Protein / genetics*
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Oncogene Proteins, Fusion*
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Phosphoric Monoester Hydrolases / genetics*
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Translocation, Genetic*
Substances
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KMT2A protein, human
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Oncogene Proteins, Fusion
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase
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Phosphoric Monoester Hydrolases