Shao-yao Gan-Cao Tang (SYGCT) is a popular Chinese herbal prescription which is composed of Paeoniae Radix and Glycyrrhizae Radix. The uric acid-lowering effects and regulatory effects on autonomic functions of SYGCT in vegetarians with asymptomatic hyperuricemia were evaluated in the present study. All the hyperuricemic vegetarians in experimental group and the normal healthy subjects in control group were administered SYGCT three times daily for 4 weeks. The blood levels of uric acid and general autonomic system function examinations were performed at baseline and after 4-week treatment. The activities of autonomic function were evaluated by a modified method from Wenger's analyses of autonomic variables. After 4-week treatment of SYGCT, a significant reduction of serum uric acid levels was found in the hyperuricemic vegetarians. SYGCT could increase the sympathetic activities of the hyperuricemic vegetarians with deficient-syndrome, but had no significant effects in the excess-syndrome subjects.