Leptospirosis is a worldwide zoonotic infection. The source of infection in humans is usually either direct or indirect contact with the urine of infected animals. Occupation is a significant risk factor for humans. Direct contact with infected animals accounts for most infections in farmers, veterinarians, abattoir workers, meat inspectors. The highest risk is associated with swine farming, slaughterhouse and meat industry workers. Most cases are diagnosed by serology. Leptospirosis may be prevented trought appropriate hygiene, sanitization, animal husbandry. It is essential to educate people working with animals or animal tissues about measures for reducing the risk of exposure to Leptospira. Protective clothing provided included an apron, gloves and rubber boots. When the risk is high, serologic testing are useful also.