Pyometra is defined as the pooling of pus in the uterus. An uncommon condition, it occurs mainly in elderly women, mostly due to constriction of the cervical canal or problems in vagina self-cleaning arising with age. We report two cases of pyometra presented with fever for over two weeks. Uterine cervical cancer occluded the cervical canal, causing pyometra in both cases. A 65-year-old woman was treated with drainage and an antibacterial agent (cefmetazole). A 30-year-old woman was treated with an antibacterial agent alone (ampicillin/sulbactam). Culture of the discharge showed polymicrobial infection including anaerobes in both cases. Although pyometra is a rare source of fever, it can cause severe complications such perforation. This disease should thus be considered as a condition that manifests with fever and/or abdominal pain in women.