New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

Jun-ya Ueda; Junko Hashimoto; Aya Nagai; Takuji Nakashima; Hisayuki Komaki; Kozue Anzai; Shigeaki Harayama; Takayuki Doi; Takashi Takahashi; Kazuo Nagasawa; Tohru Natsume; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2007.41

New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

J Antibiot (Tokyo). 2007 May;60(5):321-4. doi: 10.1038/ja.2007.41.

Authors

Jun-ya Ueda¹, Junko Hashimoto, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Kazuo Nagasawa, Tohru Natsume, Motoki Takagi, Kazuo Shin-ya

Affiliation

¹ Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC).

PMID: 17551211
DOI: 10.1038/ja.2007.41

Abstract

A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology*
Cell Line, Tumor
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Chromones / isolation & purification*
Chromones / pharmacology*
Drug Screening Assays, Antitumor
Humans
Mycelium / chemistry
Soil Microbiology
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Streptomyces / chemistry*

Substances

Antibiotics, Antineoplastic
Chromones
aureothin