After hours keeps clock researchers CRYing Overtime

David M Virshup; Daniel B Forger

doi:10.1016/j.cell.2007.05.015

After hours keeps clock researchers CRYing Overtime

Cell. 2007 Jun 1;129(5):857-9. doi: 10.1016/j.cell.2007.05.015.

Authors

David M Virshup¹, Daniel B Forger

Affiliation

¹ Department of Pediatrics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. david.virshup@hci.utah.edu

PMID: 17540165
DOI: 10.1016/j.cell.2007.05.015

Abstract

Three recent reports, including one in this issue of Cell, reveal that the circadian regulator CRY is targeted for degradation by the F box E3 ubiquitin ligase FBXL3 (Siepka et al., 2007; Busino et al., 2007; Godinho et al., 2007). These studies confirm the importance of targeted protein degradation as a key design feature of the mammalian circadian clock.

Publication types

Comment

MeSH terms

Animals
Biological Clocks*
Chronobiology Disorders
Circadian Rhythm*
Cryptochromes
F-Box Proteins / genetics*
F-Box Proteins / metabolism*
Flavoproteins / metabolism*
Mutation
Nuclear Proteins / metabolism
Ubiquitin-Protein Ligases / metabolism

Substances

Cryptochromes
F-Box Proteins
Flavoproteins
Nuclear Proteins
Ubiquitin-Protein Ligases