Objective: To explore the effect of tacrolimus on murine hair follicle cycle.
Method: Hematoxylin-eosin dyeing and reverse transcription-polymerase chain raction techniques were used.
Results: Five days after depilation, the hair follicles in both the tacrolimus group and the minoxidil group was in anagen V, while that in the vaseline group was in anagen III. vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were detected in back skin in both the tacrolimus group and the minoxidil group, but not in the vaseline group.
Conclusion: Tacrolimus can promote the growth of hair by stimulating the hair follicle to enter anagen V in mice, which may be explained by the effects of VEGF and HGF.