Acute and chronic complications of type 2 diabetes mellitus in children and adolescents

Lancet. 2007 May 26;369(9575):1823-1831. doi: 10.1016/S0140-6736(07)60821-6.

Abstract

With the increase in prevalence of type 2 diabetes mellitus in adolescents, a rise in incidence of secondary comorbidities--including hypertension, hyperlipidaemia, nephropathy, and retinopathy--is anticipated. Furthermore, findings of studies in young adults have suggested that the development and progression of clinical complications might be especially rapid when the onset of type 2 diabetes is early, raising the possibility of a serious public-health challenge in the next few decades. To date, reports of the epidemiology and natural history of secondary complications specifically in adolescents with type 2 diabetes have been scarce. Yet, we must begin to understand the extent of the coming challenge. To this end, we have reviewed reports on acute and long-term comorbidities associated with type 2 diabetes in young people and have looked at mounting evidence that this group could be at increased risk for development of early complications.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Adolescent
  • Child
  • Chronic Disease
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Ketoacidosis / epidemiology
  • Diabetic Ketoacidosis / mortality
  • Dyslipidemias / complications*
  • Dyslipidemias / epidemiology
  • Humans
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / epidemiology
  • Prevalence