A network partition algorithm for mining gene functional modules of colon cancer from DNA microarray data

Genomics Proteomics Bioinformatics. 2006 Nov;4(4):245-52. doi: 10.1016/S1672-0229(07)60005-9.

Abstract

Computational analysis is essential for transforming the masses of microarray data into a mechanistic understanding of cancer. Here we present a method for finding gene functional modules of cancer from microarray data and have applied it to colon cancer. First, a colon cancer gene network and a normal colon tissue gene network were constructed using correlations between the genes. Then the modules that tended to have a homogeneous functional composition were identified by splitting up the network. Analysis of both networks revealed that they are scale-free. Comparison of the gene functional modules for colon cancer and normal tissues showed that the modules' functions changed with their structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Colonic Neoplasms / metabolism*
  • Gene Regulatory Networks*
  • Humans
  • Oligonucleotide Array Sequence Analysis / methods*