Abstract
A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / pharmacology
-
Conjugation, Genetic*
-
Genomics*
-
Humans
-
Klebsiella pneumoniae / drug effects
-
Klebsiella pneumoniae / enzymology*
-
Klebsiella pneumoniae / genetics
-
Microbial Sensitivity Tests
-
Molecular Sequence Data
-
Plasmids / genetics*
-
Sequence Analysis, DNA*
-
beta-Lactam Resistance / genetics
-
beta-Lactamases / genetics*
-
beta-Lactamases / metabolism
Substances
-
Anti-Bacterial Agents
-
beta-lactamase CTX-M-3
-
beta-Lactamases