Neuroprotective effects of alpha2-adrenergic receptor agonists

Bernd Weber; Markus Steinfath; Jens Scholz; Berthold Bein

doi:10.1358/dnp.2007.20.3.1084644

Neuroprotective effects of alpha2-adrenergic receptor agonists

Drug News Perspect. 2007 Apr;20(3):149-54. doi: 10.1358/dnp.2007.20.3.1084644.

Authors

Bernd Weber¹, Markus Steinfath, Jens Scholz, Berthold Bein

Affiliation

¹ Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. weber@anaesthesie.uni-kiel.de

PMID: 17520091
DOI: 10.1358/dnp.2007.20.3.1084644

Abstract

Alpha2-adrenergic receptor agonists exert potent analgesic and sedative/hypnotic effects. In addition, they have been shown to be neuroprotective in various experimental models, but the molecular pathways leading to these actions are still poorly defined. This review summarizes the available literature and discusses potential mechanisms of alpha2-adrenergic receptor agonist mediated neuroprotection.

Publication types

Review

MeSH terms

Adrenergic Agonists / pharmacokinetics
Adrenergic Agonists / pharmacology*
Adrenergic Agonists / therapeutic use
Adrenergic alpha-2 Receptor Agonists*
Animals
Humans
Imidazolines / pharmacokinetics
Imidazolines / pharmacology*
Imidazolines / therapeutic use
Neuroprotective Agents / pharmacokinetics
Neuroprotective Agents / pharmacology*
Neuroprotective Agents / therapeutic use

Substances

Adrenergic Agonists
Adrenergic alpha-2 Receptor Agonists
Imidazolines
Neuroprotective Agents