Pregnancies complicated by multidrug-resistant tuberculosis and HIV co-infection in Durban, South Africa

Int J Tuberc Lung Dis. 2007 Jun;11(6):706-8.

Abstract

Setting: Tertiary hospitals in KwaZulu Natal, South Africa.

Objective: To study the impact of multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus-1 (HIV-1) co-infection during pregnancy on maternal and perinatal outcome.

Design: Prospective study performed between 1996 and 2001. Symptomatic pregnant women were investigated for TB. Those with confirmed MDR-TB were reported on.

Results: Three of five pregnant women with MDR-TB were HIV-1 co-infected. One woman decided to terminate the pregnancy and one experienced pre-term labour. Two neonates had features of growth restriction.

Conclusion: Management of pregnant women with MDR-TB in an HIV-endemic area is possible in developing countries.

MeSH terms

  • Abortion, Induced
  • Abortion, Spontaneous
  • Adolescent
  • Adult
  • Antitubercular Agents / adverse effects
  • Female
  • Fetal Growth Retardation / etiology
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV Infections / transmission
  • HIV Infections / virology
  • HIV-1*
  • Humans
  • Infectious Disease Transmission, Vertical
  • Live Birth
  • Mycobacterium tuberculosis / isolation & purification
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / microbiology
  • Pregnancy Complications, Infectious / virology
  • Prospective Studies
  • South Africa
  • Sputum / microbiology
  • Tuberculosis, Multidrug-Resistant / complications*
  • Tuberculosis, Multidrug-Resistant / diagnosis
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / microbiology
  • Tuberculosis, Multidrug-Resistant / transmission

Substances

  • Antitubercular Agents