Abstract
Even though chemistry is now in place that potentially allows high coupling efficiencies to be attained, successful coupling is usually a challenge when so-called "difficult sequences" is encountered in peptide synthesis. Some factors that affect the coupling efficiency have been discussed and related methods to overcome those obstacles have been introduced in present review. All suggestions proposed here are valuable and also feasible to improve the coupling completeness in both liquid-phase or solid-phase
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acylation
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Amino Acid Sequence
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Molecular Structure
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Organophosphorus Compounds / chemistry
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Peptide Fragments / chemical synthesis*
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Peptide Fragments / chemistry
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Peptides / chemical synthesis*
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Peptides / chemistry
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Proline / analogs & derivatives
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Proline / chemistry
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Resins, Synthetic / chemistry
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Temperature
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Thiazoles / chemistry
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Thiocyanates / chemistry
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Triazoles / chemistry
Substances
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Organophosphorus Compounds
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Peptide Fragments
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Peptides
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Resins, Synthetic
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Thiazoles
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Thiocyanates
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Triazoles
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benzotriazol-1-yloxtri (pyrrolidinol)phosphonium hexafluorophosphate
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pseudoproline
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Proline
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potassium thiocyanate