Abstract
The synthesis of (4,5,6-13C)-deoxymannojirimycin is described. The route employed is based on Sharpless asymmetric epoxidation of (1,2,3-13C)(E)-2,4-pentadien-1-ol and uses ring-closing metathesis as a key step. The labeled compound may be easily used for protein-binding experiments using NMR spectroscopic methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Deoxynojirimycin / analogs & derivatives
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1-Deoxynojirimycin / chemical synthesis
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1-Deoxynojirimycin / chemistry*
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1-Deoxynojirimycin / pharmacology*
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Carbon Isotopes
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Glycoside Hydrolases / antagonists & inhibitors*
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Indicators and Reagents
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Isotope Labeling
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
Substances
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Carbon Isotopes
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Enzyme Inhibitors
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Indicators and Reagents
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1-Deoxynojirimycin
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Glycoside Hydrolases