Abstract
Statins inhibit the dimerization of beta-secretase [BACE (beta-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal sequence for these reactions in the assembly of the BACE complex, which may provide targets for the treatment of Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / drug therapy
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Alzheimer Disease / metabolism
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Amyloid Precursor Protein Secretases / chemistry
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Amyloid Precursor Protein Secretases / metabolism*
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Amyloid beta-Peptides / metabolism
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Aspartic Acid Endopeptidases / metabolism
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Cell Line
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Cholesterol / metabolism
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Dimerization
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Lipid Metabolism / drug effects
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Models, Biological
Substances
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Amyloid beta-Peptides
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Cholesterol
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Amyloid Precursor Protein Secretases
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Aspartic Acid Endopeptidases
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BACE1 protein, human