Synthesis of penaresidin derivatives and its biological activity

Bioorg Med Chem. 2007 Jul 15;15(14):4910-6. doi: 10.1016/j.bmc.2007.04.049. Epub 2007 Apr 29.

Abstract

A series of stereoisomers for the azetidine ring of penaresidin B was synthesized and their cytotoxic and antimicrobial activities were evaluated. Among six synthetic isomers 1-6, isomers 4 and 5 showed relatively potent cytotoxic activity against A549 (lung) and HT29 (colon) tumor cells as well as antibacterial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemical synthesis
  • Alkanes / chemistry*
  • Alkanes / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Heterocyclic Compounds, 1-Ring / chemical synthesis
  • Heterocyclic Compounds, 1-Ring / chemistry*
  • Heterocyclic Compounds, 1-Ring / pharmacology*
  • Humans
  • Isomerism
  • Molecular Structure
  • Organic Chemicals / chemical synthesis
  • Organic Chemicals / chemistry*
  • Organic Chemicals / pharmacology*
  • Structure-Activity Relationship

Substances

  • Alkanes
  • Anti-Bacterial Agents
  • Heterocyclic Compounds, 1-Ring
  • Organic Chemicals
  • penaresidin