Abstract
A series of stereoisomers for the azetidine ring of penaresidin B was synthesized and their cytotoxic and antimicrobial activities were evaluated. Among six synthetic isomers 1-6, isomers 4 and 5 showed relatively potent cytotoxic activity against A549 (lung) and HT29 (colon) tumor cells as well as antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis
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Alkanes / chemistry*
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Alkanes / pharmacology*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Heterocyclic Compounds, 1-Ring / chemical synthesis
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Heterocyclic Compounds, 1-Ring / chemistry*
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Humans
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Isomerism
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Molecular Structure
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Organic Chemicals / chemical synthesis
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Organic Chemicals / chemistry*
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Organic Chemicals / pharmacology*
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Structure-Activity Relationship
Substances
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Alkanes
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Anti-Bacterial Agents
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Heterocyclic Compounds, 1-Ring
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Organic Chemicals
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penaresidin