Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea

Antimicrob Agents Chemother. 2007 Jul;51(7):2625-7. doi: 10.1128/AAC.00107-07. Epub 2007 May 14.

Abstract

The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / epidemiology*
  • Community-Acquired Infections / microbiology
  • DNA, Bacterial
  • Drug Resistance, Bacterial / genetics*
  • Erythromycin / pharmacology
  • Fluoroquinolones / pharmacology
  • Genes, Bacterial
  • Hospitals
  • Humans
  • Korea / epidemiology
  • Levofloxacin
  • Macrolides / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Epidemiology / methods*
  • Mutation
  • Ofloxacin / pharmacology
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology
  • Polymerase Chain Reaction
  • Prevalence
  • Reserpine / pharmacology
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / microbiology
  • Retrospective Studies
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / isolation & purification

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Fluoroquinolones
  • Macrolides
  • Erythromycin
  • Levofloxacin
  • Reserpine
  • Ofloxacin