Abstract
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagic Escherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -independent manners.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Escherichia coli O157 / genetics*
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Escherichia coli O157 / growth & development
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Escherichia coli O157 / metabolism
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Escherichia coli Proteins / genetics*
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Escherichia coli Proteins / metabolism
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Gene Expression Regulation, Bacterial
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Genes, Bacterial
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Humans
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Intestine, Large / cytology
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Intestine, Large / microbiology
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Models, Genetic
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Molecular Sequence Data
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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Sequence Homology, Nucleic Acid
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Trans-Activators / genetics*
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Trans-Activators / metabolism
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Transcription, Genetic
Substances
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Escherichia coli Proteins
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LEE protein, E coli
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Phosphoproteins
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QseA protein, E coli
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Trans-Activators