Human leukocyte antigens HLA DRB1 influence clinical outcome of chronic lymphocytic leukemia?

Haematologica. 2007 May;92(5):710-1. doi: 10.3324/haematol.10910.

Abstract

We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. Neither of the alleles was associated with B-CLL clinical characteristics or mortality. HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival (p=0.007, p=0.002). Our results suggest that HLA-restricted adaptive immunity influences CLL outcome.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Female
  • Gene Frequency
  • Genes, MHC Class II
  • HLA-DR Antigens / analysis*
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Humans
  • Kaplan-Meier Estimate
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / mortality
  • Male
  • Middle Aged
  • Survival Analysis
  • T-Lymphocytes / immunology
  • Treatment Outcome

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*01 antigen
  • HLA-DRB1*02 antigen