[Pharmacological mechanisms of Doxorubicin activity (DOX) - current state of knowledge]

Dorota Łubgan; Agnieszka Marczak; Mateusz Walczak; Luitpold Distel; Zofia Jóźwiak

[Pharmacological mechanisms of Doxorubicin activity (DOX) - current state of knowledge]

Przegl Lek. 2006;63(9):782-8.

[Article in Polish]

Authors

Dorota Łubgan¹, Agnieszka Marczak, Mateusz Walczak, Luitpold Distel, Zofia Jóźwiak

Affiliation

¹ Katedra Termobiologii, Instytut Biofizyki, Uniwersytet Łódzki.

PMID: 17479870

Abstract

Doxorubicin (DOX) belongs to the anthracycline antibiotics, widely used in the treatment of various types of malignancies. This review presents recent data about mechanisms of the drug action.

Publication types

English Abstract
Review

MeSH terms

Animals
Antibiotics, Antineoplastic / pharmacology*
Apoptosis / drug effects*
Cell Nucleus / drug effects
DNA Repair
Doxorubicin / pharmacology*
Humans
Molecular Structure
Reactive Oxygen Species / metabolism
Tumor Cells, Cultured / drug effects*

Substances

Antibiotics, Antineoplastic
Reactive Oxygen Species
Doxorubicin