The vapor-liquid equilibrium of binary mixtures of xenon + SF6 has been measured at nine temperatures from 235.34 to 295.79 K and pressures up to 6.5 MPa. The mixture critical line is found to be continuous between the critical points of the pure components, and hence, the system can be classified as type I phase behavior in the scheme of van Konynenburg and Scott. The excess Gibbs free energies have been calculated, and the experimental results have been interpreted using the statistical associating fluid theory for potentials of variable range (SAFT-VR). Additionally, the SAFT-VR equation has been used to model other systems involving SF6 and alkanes, illustrating the predictability of the approach and further demonstrating the transferability of parameters between binary mixtures involving alkanes and xenon.