Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1

Antimicrob Agents Chemother. 2007 Jun;51(6):2260-4. doi: 10.1128/AAC.00242-07. Epub 2007 Apr 16.

Abstract

beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electrophoresis, Gel, Pulsed-Field
  • Haemophilus Infections / microbiology
  • Haemophilus Infections / veterinary
  • Haemophilus parasuis / drug effects*
  • Haemophilus parasuis / enzymology
  • Haemophilus parasuis / genetics
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Plasmids*
  • Sequence Analysis, DNA
  • Swine / microbiology
  • Swine Diseases / microbiology
  • beta-Lactam Resistance / genetics*
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology*

Substances

  • beta-Lactams
  • beta-lactamse ROB-1
  • beta-Lactamases

Associated data

  • GENBANK/DQ840517
  • GENBANK/DQ845801
  • GENBANK/DQ845802
  • GENBANK/DQ845803
  • GENBANK/DQ845805
  • GENBANK/DQ845806
  • GENBANK/DQ845807
  • GENBANK/DQ845808