Evaluation of moxalactam with the BD phoenix system for detection of methicillin resistance in coagulase-negative staphylococci

H Pupin; H Renaudin; O Join-Lambert; C Bébéar; F Mégraud; P Lehours

doi:10.1128/JCM.00578-07

Evaluation of moxalactam with the BD phoenix system for detection of methicillin resistance in coagulase-negative staphylococci

J Clin Microbiol. 2007 Jun;45(6):2005-8. doi: 10.1128/JCM.00578-07. Epub 2007 Apr 11.

Authors

H Pupin¹, H Renaudin, O Join-Lambert, C Bébéar, F Mégraud, P Lehours

Affiliation

¹ CHU de Bordeaux, Hôpital Pellegrin, Laboratoire de Bactériologie, Place Amélie Raba Léon, 33076 Bordeaux, France.

Abstract

The performance of moxalactam with the BD Phoenix system for the detection of methicillin resistance in coagulase-negative staphylococci was evaluated by use of a collection of 186 strains. Moxalactam was a better drug as an indicator of methicillin resistance for mecA-positive strains than oxacillin and cefoxitin were. For strains other than Staphylococcus saprophyticus, a moxalactam MIC >16 microg/ml was indicative of methicillin resistance.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics
Coagulase / metabolism*
Humans
Methicillin Resistance* / genetics
Microbial Sensitivity Tests / methods
Microbial Sensitivity Tests / standards
Moxalactam / pharmacology*
Penicillin-Binding Proteins
Reagent Kits, Diagnostic*
Staphylococcus / classification
Staphylococcus / drug effects*
Staphylococcus / enzymology
Staphylococcus / genetics

Substances

Anti-Bacterial Agents
Bacterial Proteins
Coagulase
Penicillin-Binding Proteins
Reagent Kits, Diagnostic
mecA protein, Staphylococcus aureus
Moxalactam