A new nucleosidyl-peptide antibiotic, sansanmycin

Yunying Xie; Ruxian Chen; Shuyi Si; Chenghang Sun; Hongzhang Xu

doi:10.1038/ja.2007.16

A new nucleosidyl-peptide antibiotic, sansanmycin

J Antibiot (Tokyo). 2007 Feb;60(2):158-61. doi: 10.1038/ja.2007.16.

Authors

Yunying Xie¹, Ruxian Chen, Shuyi Si, Chenghang Sun, Hongzhang Xu

Affiliation

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Tiantanxili, Beijing, PR China.

PMID: 17420567
DOI: 10.1038/ja.2007.16

Abstract

A new nucleosidyl-peptide antibiotic, sansanmycin, was isolated from an unidentified Streptomyces sp SS. The structure of sansanmycin was elucidated by analyses of its alkaline hydrolysate and spectroscopic analyses. Sansanmycin exhibits antibacterial activity against Mycobacterium tuberculosis H(37)Ra and Pseudomonas aeruginosa with MIC values of 10 and 12.5 mug/ml, respectively.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Gas Chromatography-Mass Spectrometry
Isomerism
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Oligopeptides / chemistry
Oligopeptides / isolation & purification*
Oligopeptides / pharmacology*
Pseudomonas aeruginosa / drug effects
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
Uridine / analogs & derivatives*
Uridine / chemistry
Uridine / isolation & purification
Uridine / pharmacology

Substances

Anti-Bacterial Agents
Oligopeptides
sansanmycin
Uridine