Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis

Clin Exp Rheumatol. 2007 Jan-Feb;25(1):96-8.

Abstract

The concept of amyopathic dermatomyositis or dermatomyositis sine myositis, is contentious, particularly within paediatrics. We report an 8-year-old girl presenting with dermatological dermatomyositis without muscle weakness. Muscle biopsy changes are described, in particular, the absence of MHC class 1 over expression. This supports the concept of amyopathic dermatomyositis as a subgroup of juvenile dermatomyositis (JDM) and suggests that immunohistological analysis may be a valuable in excluding a myositic element in such cases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Child
  • Dermatomyositis / diagnosis
  • Dermatomyositis / immunology*
  • Dermatomyositis / pathology
  • Female
  • Genes, MHC Class I
  • HLA Antigens / metabolism*
  • Humans
  • Muscle Weakness
  • Muscle, Skeletal / immunology
  • Muscle, Skeletal / pathology*

Substances

  • HLA Antigens