Abstract
The aim of this study was to investigate the antibacterial and the cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and of some natural products (sclareol, sclareolide and ambrox). The antibacterial and the cytotoxic activity were determined by the dilution method. Sclareolide, ambrox and sclareol demonstrated a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. The acetonic extract of the flowers of Salvia sclarea has a significant cytotoxic activity against Hep-2 cells.
MeSH terms
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Acetone / chemistry*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Diterpenes / pharmacology*
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Dose-Response Relationship, Drug
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / growth & development
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Flowers
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Furans / pharmacology*
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Humans
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Inhibitory Concentration 50
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Liver Neoplasms / pathology
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Microbial Sensitivity Tests
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Naphthalenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Salvia*
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Solvents / chemistry*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Diterpenes
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Furans
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Naphthalenes
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Plant Extracts
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Solvents
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Acetone
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sclareolide
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ambrox
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sclareol