Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet
Bull Exp Biol Med. 2006 Oct;142(4):458-60.
doi: 10.1007/s10517-006-0391-x.
[Article in
English,
Russian]
Affiliation
- 1 Institute of Pharmacology, Volgograd State Medical University. farm@interdacom.ru
Abstract
Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not increase its level. L-Carnitine, but not racemate and D-stereoisomer, promoted recovery of the skeletal muscle fiber thickness and exercise performance of rats.
MeSH terms
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Animals
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Carnitine / deficiency*
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Carnitine / pharmacology*
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Male
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Models, Animal
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Muscle, Skeletal / drug effects
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Muscle, Skeletal / physiology*
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Physical Conditioning, Animal*
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Rats
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Stereoisomerism
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Swimming