Abstract
Transmission of human herpesvirus 8 (HHV-8) may occur through various routes including breastfeeding and sexual intercourse. We attempted to detect HHV-8 infection in nine HIV-positive couples discordant for Kaposi's sarcoma who maintained a monogamous sexual relationship for at least one year. By quantitative real-time polymerase chain reaction and HHV-8 genotyping we provide strong evidence for the sexual transmission of HHV-8 in this unique cohort.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antiretroviral Therapy, Highly Active
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Cohort Studies
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DNA, Viral / analysis
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Female
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Genotype
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HIV Seropositivity / complications
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HIV Seropositivity / drug therapy
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HIV Seropositivity / virology*
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Herpesvirus 8, Human / isolation & purification*
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Humans
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Leukocytes, Mononuclear / virology
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Male
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Middle Aged
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Polymerase Chain Reaction / methods
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Sarcoma, Kaposi / complications
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Sarcoma, Kaposi / virology*
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Sequence Homology, Amino Acid
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Sexual Behavior