Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1

J M Rodríguez-Martínez; C Velasco; I García; M E Cano; L Martínez-Martínez; A Pascual

doi:10.1128/AAC.01444-06

Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1

Antimicrob Agents Chemother. 2007 Jun;51(6):2236-9. doi: 10.1128/AAC.01444-06. Epub 2007 Apr 2.

Authors

J M Rodríguez-Martínez¹, C Velasco, I García, M E Cano, L Martínez-Martínez, A Pascual

Affiliation

¹ Department of Microbiology, University of Seville, Sanchez Pizjuan s/n, Seville 41009, Spain. jmrodriguez@us.es

Abstract

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Colony Count, Microbial
Dose-Response Relationship, Drug
Drug Resistance, Bacterial / genetics*
Enterobacteriaceae / drug effects*
Enterobacteriaceae / genetics
Enterobacteriaceae / growth & development
Escherichia coli Proteins / genetics
Fluoroquinolones / pharmacology*
Humans
Microbial Sensitivity Tests
Mutation*
Plasmids*

Substances

Anti-Infective Agents
Bacterial Proteins
Escherichia coli Proteins
Fluoroquinolones
Qnr protein, E coli
Qnr protein, Klebsiella pneumoniae